A Bright Future for Immunotherapy: CAR T-Cell Therapy Promises Revolutionary Changes

Chimeric antigen receptor (CAR) T-cell therapy is an innovative technology that has fundamentally changed approaches to treating certain forms of oncological diseases. The anticipated development of CAR T cell-based therapies in the near future is expected to broaden the range of therapeutic targets and holds the potential to decrease treatment costs, thereby expanding accessibility for a broader patient population. This review article provides an overview of the practical applications of CAR T-cell therapy in clinical settings, describes the global market for commercial CAR T-cell products and offers insights into the future landscape of CAR T-cell therapy. We focus on emerging therapies, novel targets and strategic approaches to improve treatment efficacy and reduce costs. Furthermore, we discuss the progress of CAR T-cell therapy in Russia, where this type of therapy is in the early stages of development but already demonstrates promising potential. PEER REVIEWED ARTICLE **Peer reviewers:** Dr Andriyana K. Bankova, National Specialized Hospital for Hematological Diseases, Sofia, Bulgaria Erik Aerts, Hematology Nurses & Healthcare Professionals Group, University Hospital Zurich, Zurich, Switzerland Received on November 06, 2024; accepted after peer review on December 28, 2024; published online on December 30, 2024.