Anti-urolithiatic effect of Ethanolic extract of Bryophyllum pinnatum (Lam) against Chemicals Induced Renal Calculi in rats

Objective: The purpose of research was to establish whether an ethanolic extract of Bryophyllum pinnatum (Lam) helps to protect rats against chemically induced urolithiasis. Materials and methods: Ethylene glycol-induced urolithiasis: For 28 days, an oral dose of 0.75% v/v ethylene glycol was given to induce urolithiasis. The animals were split up into six groups, each with six animals. For 28 days, Group I animals were administered with distilled water. For a period of 28 days, drinking water containing 0.75% v/v ethylene glycol was given to all groups except group I. Group III animals (standard group) were given 500mg/kg of Cystone from the 15th to the 28th day, Group IV, V, and VI were given oral doses of 50, 100, and 200mg/kg of Bryophyllum pinnatum. Urolithiasis produced by sodium oxalate: In this model, the animals were split into six groups, each consisting of six animals. Group I animals (control group) were administered with distilled water. Group II was given sodium oxalate (70mg/kg i.p.) as a lithiatic control. Group III animals were administered with 500mg/kg of the standard drug Cystone. Groups IV, V, and VI animals were administered Bryophyyum pinnatum orally at a dosage of 50, 100, and 200mg/kg. Result: The outcome showed that, in comparison to lithiatic control rats, the ethanolic extract of Bryophyllum pinnatum significantly decreased the concentrations of calcium, uric acid, magnesium, urea and creatinine in blood serum as well as oxalate, calcium, uric acid, magnesium, urea and creatinine in urine. Conclusion: By inhibiting kidney crystal deposition, the ethanolic extract of Bryophyllum pinnatum (lam) exhibits favorable action against urolithiasis.