Development of Fast Dissolving Films of Ondansetron: Formulation and Evaluation

Ondansetron, a potent antiemetic used to prevent nausea and vomiting associated with chemotherapy, radiotherapy, and post-surgical procedures, is typically administered in the form of tablets or injections. However, these conventional dosage forms may pose challenges, such as difficulty in swallowing, poor patient compliance, and variability in gastrointestinal absorption. Fast dissolving films (FDFs) have emerged as a promising alternative, offering a rapid onset of action, ease of administration, and enhanced patient compliance. This study aimed to formulate, develop, and evaluate ondansetron-loaded FDFs to improve its bioavailability and therapeutic efficacy. Ondansetron FDFs were prepared using the solvent casting method, incorporating polymers like hydroxypropyl methylcellulose, Xanthan gum, and Sodium starch glycolate. The film thickness ranged from 0.098 to 0.110 mm, ensuring uniformity across formulations. The drug content was found to be consistent, with maximum 99.80% in F7. The dissolution profile indicated that 99% of ondansetron was released within 5min in a simulated dissolution medium. The disintegration time varied from 8 to 26 seconds, ensuring a rapid onset of action. The folding endurance showed elongation at break of 110 times in F7, providing adequate flexibility and strength for handling. Stability studies at 40°C/75% RH over three months revealed no significant degradation, with the drug content remaining at 98.96% and no change in dissolution behavior.