Formulation and Evaluation of Spansules Containing Azithromycin and Meropenem

This study focused on developing and evaluating spansules containing azithromycin and meropenem enteric-coated granules for targeted and controlled drug delivery. Azithromycin and meropenem granules were separately prepared using the wet granulation method and coated with Eudragit L100 and HPMC phthalate for gastric resistance. The optimized granules were combined in predefined ratios and encapsulated in gelatin capsules. Physicochemical evaluations revealed uniform weight and drug content within pharmacopeial limits. Surface morphology assessed via SEM confirmed uniform and intact enteric coatings. In vitro drug release studies indicated negligible drug release in gastric fluid (pH 1.2), with a significant release in simulated intestinal fluid (pH 6.8). The cumulative drug release over 12 hours reached 96.5% for azithromycin and 94.8% for meropenem, demonstrating effective controlled release. Stability studies conducted at 40°C/75% RH for three months showed no significant changes in drug content or release profile, confirming formulation stability. These results suggest that the developed spansules provide a promising approach for improving the therapeutic efficacy and patient compliance of azithromycin and meropenem therapy by ensuring targeted delivery and prolonged release. The study concludes that this novel formulation could address challenges in the treatment of severe bacterial infections.