Advances in Floating Drug Delivery Systems: A Promising Approach for Gastroretentive Therapy

Dosage forms of gastric emptying is extremely variable process and having ability to prolonged and control emptying time of dosage forms, which retain in the stomach for a longer time of period than the conventional dosage forms. Some challenges arise when formulating controlled release systems to improve absorption and bioavailability. One challenge involves the difficulty in restricting the dosage form to intended region of the GIT. The process of drug absorption from the GIT is intricate and influenced by numerous variables. It is commonly recognized that the degree of drug absorption in the GIT correlates with the duration of contact with the mucosa of the small intestine. Therefore, the transit time through the small intestine is a critical parameter for drugs that experience incomplete absorption. A concise overview is provided of fundamental human physiology, encompassing details about gastric emptying, motility patterns, and the physiological and formulation variables that influence the overall gastric emptying process. Gastroprotective systems have the capacity to stay within the stomach for extended periods, thereby effectively prolonging the residence time of drugs in the gastric region. This prolonged gastric retention enhances bioavailability, diminishes drug wastage, and improves the solubility of drugs that exhibit low solubility in high pH environments. It is applications for local drug delivery to the stomach, proximal small intestines. Gastro retention contributes to ensuring improved accessibility for novel products with innovative therapeutic potentials, offering significant advantages for patients.