Preliminary study of the influence of maternal and neonatal NOS3 (rs1799983), IL1B (rs1143634) genes variants and their intergenic interaction on the development of hypoxic-ischemic encephalopathy in newborns in the context of treatment planning
Conclusions: The significance of the intergenic maternal combination of 894GG/3953CT genotypes for the eNOS and IL1B genes and the intergenic combination of neonatal 894GG (eNOS)/maternal 3953CT (IL-1B) genotypes in the development of HIE in newborns has been proven. Associations of maternal and neonatal 894TT genotypes for the eNOS gene with the development of severe asphyxia, bradycardia, and respiratory failure were found in newborns with HIE.
Authors
- Yuliia Cherniavska (ORCID: https://orcid.org/0000-0002-4522-7538)
- Liliia Fishchuk (ORCID: https://orcid.org/0000-0001-9999-7389)
- Zoia Rossokha (ORCID: https://orcid.org/0000-0002-4767-7364)
- A. Davydenko (ORCID: https://orcid.org/0000-0002-4042-644X)
- V. Pokhylko (ORCID: https://orcid.org/0000-0002-1848-0490)
Institutions
- Ukrainian Medical Stomatological Academy (UA)
- Shupyk National Healthcare University of Ukraine (UA)
- Poltava University of Economics and Trade (UA)
- Poltava State Agrarian University (UA)
Publication Details
- Journal
- Wiadomości Lekarskie
- Published
- 2024-12-30
- DOI
- https://doi.org/10.36740/wlek/197108
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00