Research Progress on Reproductive Toxicity and Reversibility of <i>Tripterygium wilfordii</i> Based on Gender Differences

Tripterygium wilfordii Hook F. (TwHF), a member of the Celastraceae family and belonging to the genus Tripterygium , is a vine-like shrub. It contains numerous active components, such as Tripterygium glycosides (GTW) and triptolide (TP), widely known for their significant reproductive toxicity. This toxicity is characterized by its detrimental effects on the testes and ovaries, leading to reduced libido, apoptosis of germ and follicle cells, and abnormal secretion of sex hormones. Thus, it is necessary to explore the mechanisms behind TwHF’s reproductive toxicity, which will lead to advancements in detoxification and efficacy enhancement strategies. This article offers a comprehensive overview and analysis of the research conducted on reproductive toxicity and its reversibility induced by TwHF, aiming to provide a reference for its rational use in clinical settings.