Comparison of Investigator-Reported and Centrally Adjudicated Heart Failure Outcomes in the EMPEROR-Preserved Trial
Investigator adjudication is an alternative to a CEC with similar accuracy and faster event accumulation in HFpEF. The use of granular (SCTI) criteria did not improve trial performance. Our data suggest that a broader definition of an HHF event could be particularly beneficial in HFpEF clinical trials. (EMPagliflozin outcome tRial in Patients with chronic heart Failure With Preserved Ejection Fraction; NCT03057951).
Authors
- Tomoko Iwata (ORCID: https://orcid.org/0000-0002-9634-9738)
- Inder S. Anand (ORCID: https://orcid.org/0000-0003-1308-4963)
- Martina Brueckmann (ORCID: https://orcid.org/0000-0003-1215-0746)
- John R. Teerlink (ORCID: https://orcid.org/0000-0001-9527-0852)
- Markus Haass
- Stuart Pocock (ORCID: https://orcid.org/0000-0003-2212-4007)
- Steen Pehrson (ORCID: https://orcid.org/0000-0002-7149-4613)
- Peter Carson
- Faiez M. Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
- Milton Packer (ORCID: https://orcid.org/0000-0003-1828-2387)
- Stefan D. Anker
- Tomasz Gąsior (ORCID: https://orcid.org/0000-0001-5088-4164)
- Wolfram Doehner (ORCID: https://orcid.org/0000-0001-7598-708X)
- Alan B. Miller (ORCID: https://orcid.org/0000-0003-3504-6239)
- João Pedro Ferreira (ORCID: https://orcid.org/0000-0002-2304-6138)
- Michel Komajda (ORCID: https://orcid.org/0000-0002-3010-5589)
- Javed Butler
Institutions
- San Francisco VA Medical Center (US)
- Boehringer Ingelheim (Germany) (DE)
- National and Kapodistrian University of Athens (GR)
- Heidelberg University (DE)
- University of Florida Health (US)
- Rigshospitalet (DK)
- Humboldt-Universität zu Berlin (DE)
- London School of Hygiene & Tropical Medicine (GB)
- Lung Institute (US)
- Beebe Healthcare (US)
- University of Minnesota Medical Center (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- University General Hospital Attikon (GR)
- Minneapolis VA Medical Center (US)
- WSB University (PL)
- Baylor Scott & White Health (US)
- Université de Lorraine (FR)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.jchf.2024.10.021
- Citations
- 3
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- Boehringer Ingelheim