Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling
Strategic delivery of hydrogels to the newly formed myocardial infarction (MI) is an area of active investigation and offers high target specificity for releasing a small molecule therapeutic payload. This study examined the effects of delayed post-MI delivery (pigs, 3 days post-MI) of a shear-thinning hydrogel which encapsulated and released a small molecule matrix metalloproteinase inhibitor. The results demonstrated the feasibility and efficacy of targeted delivery of a shear-thinning injectable hydrogel containing a small molecule matrix metalloproteinase inhibitor to attenuate post-MI remodeling.
Authors
- A. Whalen
- Jason A. Burdick (ORCID: https://orcid.org/0000-0002-2006-332X)
- Tarek Shazly (ORCID: https://orcid.org/0000-0001-6214-5887)
- Francis G. Spinale (ORCID: https://orcid.org/0000-0003-0529-5605)
- Lisa Freeburg
- Joshua E. Mealy
- William M. Torres
- Shayne C. Barlow
- Chima V. Maduka
Institutions
- University of South Carolina (US)
- University of Colorado Boulder (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.jacbts.2024.11.009
- Citations
- 4
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Institutes of Health