Synergistic effects of doxorubicin and coumarin on colorectal cancer cell proliferation and EMT modulation: in silico and in vitro study
Our findings validate the synergistic effect of DOX and coumarin in inhibiting the proliferation of C26 cells and propose the involvement of the Wnt pathway as a downstream mediator in this treatment. Future research is required to confirm the clinical applicability of this combined treatment for CRC and to elucidate its mechanisms within the body.
Authors
- Azhdar Heydari (ORCID: https://orcid.org/0000-0002-0617-6977)
- Majid Nejati (ORCID: https://orcid.org/0000-0001-6024-5331)
- Atena Abed
- Hamed Mirzaei (ORCID: https://orcid.org/0000-0002-9399-8281)
- Merat Karimi (ORCID: https://orcid.org/0000-0001-6538-4859)
- Mahsa Khakparaghi
Institutions
- University of Kashan (IR)
- Shahrekord University of Medical Sciences (IR)
- Kashan University of Medical Sciences (IR)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1097/ms9.0000000000002922
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00