P-1767. Understanding Antibiotic Prescribing Practices by utilizing WHO's AWaRe Criteria in a tertiary care hospital in South India: A Prospective Observational study

Abstract Background Antibiotic resistance is a significant threat globally and the inappropriate use of antibiotics leads to subsequent rise in the antimicrobial resistance causing challenge in antimicrobial stewardship programs [AMS]. Assessment of Antimicrobial use by using World health organization [WHO] categorization of Antibiotics into ACCESS, WATCH, RESERVE [AWaRe]. Methods The prospective Observational study was conducted in a tertiary care hospital in the period of one month APRIL [01.04.24 -30.04.24] using a tool containing patient’s demographic data, AWaRe classification, their indications, culture reports and prescribing practices in hospitalized patients Results out of 1236 hospitalized patients 246 patient receive antibiotics. The results of the collected data in the following table ANTIBIOTIC CATEGORY- ACCESS – (33.3%)WATCH – (63.4 %)RESERVE – (3.25%)DoxycyclineMetronidazole6.9%2.1%CeftriaxoneCefuroximePiperacillin - TazobactumCefoperazone – SulbactumMeropenem28.1%24.8%22.4%13.8%7.3%FosfomycinTigecyclineLinezolid0.81%0.4%0.4%ID REFERENCEYes26.3%No74.6%INDICATIONSEmpirical30.5%Definitive16.3%Prophylaxis48.9%Empirical to Definitive6 Conclusion The data indicates a predominance use of antibiotics in the "Watch" category, with Ceftriaxone (28.1%), Cefuroxime (24.8%), and Piperacillin-Tazobactam (22.4%) being the most commonly used antibiotics and most of the antibiotics are given Empirically (30.5%) . A quarter of antibiotics are referenced in Infectious Disease. This highlights the importance of careful antibiotic stewardship to combat antimicrobial resistance and ensure effective treatment. Disclosures All Authors: No reported disclosures