Patient-Derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas
Our study establishes PDO and PDX models as robust platforms for studying SRCC and identifying potential therapeutic strategies. Combining FOLFIRI with paclitaxel/vincristine or chloroquine alone inhibits tumor growth and prevents peritoneal metastasis, showing promise for clinical translation. These findings suggest that combining FOLFIRI with intraperitoneal paclitaxel warrants further investigation in phase I clinical trials for patients with SRCC.
Authors
- Nandini Verma (ORCID: https://orcid.org/0000-0001-5260-8999)
- Nazia Chaudhary (ORCID: https://orcid.org/0009-0008-8993-5975)
- Poonam Gera (ORCID: https://orcid.org/0000-0001-7709-1594)
- Sanjeev Redkar
- Sorab N. Dalal (ORCID: https://orcid.org/0000-0001-6883-7550)
- Avanish Saklani (ORCID: https://orcid.org/0000-0003-4498-7612)
- Satishkumar Singh (ORCID: https://orcid.org/0000-0001-9957-9566)
- Vikas Ostwal (ORCID: https://orcid.org/0000-0002-0067-4748)
- Alessandro La Ferlita (ORCID: https://orcid.org/0000-0002-3680-3177)
- Rahul Thorat (ORCID: https://orcid.org/0000-0001-5059-0342)
- Vaishali Kailaje (ORCID: https://orcid.org/0000-0002-4433-7751)
- B Akshaya
- Munita Bal (ORCID: https://orcid.org/0000-0002-0345-5620)
- Lalit Sehgal (ORCID: https://orcid.org/0000-0002-1151-5427)
- Mufaddal Khuzema Kazi (ORCID: https://orcid.org/0000-0002-3295-0006)
- Bhagya Shree Choudhary (ORCID: https://orcid.org/0009-0006-1738-9683)
- Nileema Khapare
- Showket Yahya (ORCID: https://orcid.org/0000-0001-6509-7032)
- Eeshrita Jog (ORCID: https://orcid.org/0009-0002-2618-9166)
- Afiya Dalwai
Institutions
- Homi Bhabha National Institute (IN)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Tata Memorial Hospital (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
- The Ohio State University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2329
- Citations
- 8
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.86