P-538. People with HIV in the US switching to cabotegravir + rilpivirine long-acting (CAB+RPV LA) from oral antiretroviral therapy (ART) have numerous real-world benefits, including high adherence and treatment satisfaction

Abstract Background CAB+RPV LA is a complete HIV regimen which offers less frequent (monthly or every 2 months) dosing than daily oral ART. This real-world study provides additional utilization data of CAB+RPV LA and characterizes the experiences of people with HIV (PWH) receiving CAB+RPV LA in the US. Methods Data were obtained from the Adelphi HIV Disease Specific Programme™, a real-world, cross-sectional survey containing retrospective longitudinal data of healthcare professionals (HCP) and their PWH on CAB+RPV LA and over two periods (Jul 2021-Mar 2022 and Sept 2023-Feb 2024). HCPs reported demographics, clinical characteristics, and adherence for PWH on CAB+RPV LA aged ≥18 years. PWH surveys included treatment satisfaction, treatment preference and health-related quality of life (HRQoL) (HIV-specific PozQoL [score range 13-65], and EQ-5D-5L-US [score range 0-1]). Data were analyzed descriptively. Results HCPs (n=77) reported data for 237 PWH on CAB+RPV LA treatment for a median [IQR] of 1.0 [0.5, 1.7] years (n=202) at time of data collection, with 65% receiving CAB+RPV LA every 2 months (n=205). Mean age was 42 years, 20% were cisgender female, 43% were non-white (n=205) (Table 1). Top HCP-reported reasons for initiating CAB+RPV LA were tolerability (51%) and virologic potency (50%) (Figure 1). Top PWH-reported reasons for initiating CAB+RPV LA were “more convenient for my life” (43%) and “more convenient when travelling” (36%) (Figure 1). High levels of HCP-reported adherence were seen: 92% (n=205) of PWH received injections either early or within ± 7-day dosing window despite only 64% (n=103) of PWH reported to be completely adherent to prior oral ART. HCP-reported treatment satisfaction was high (93% satisfied/very satisfied). Of PWH who completed a survey, 95% (38/40) were satisfied/very satisfied with CAB+RPV LA. PWH had high HRQoL (PozQoL summary score 49.0 [SD 8.3; n=38] and EQ-5D-5L-US mean 0.88 [SD 0.14], n=39). PWH (82%) reported that fitting injection visits into their schedule was easy/extremely easy (Figure 2). CAB+RPV LA was preferred by 93%, and PWH reported numerous benefits of in-person visits to receive CAB+RPV LA (Figure 2). Conclusion PWH receiving CAB+RPV LA are adherent, highly satisfied, have high HRQoL, prefer LA regimens and reported benefits of in-person visits. Disclosures Andrew P. Brogan, PhD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Tim Holbrook, BSc, Adelphi Real World: Employee|ViiV Healthcare: The Adelphi Real World Disease Specific Programme is wholly owned by Adelphi Real World; ViiV healthcare is one subscriber and paid for the analysis Fritha Hennessy, PhD, Adelphi Real World: Employee|ViiV Healthcare: The Adelphi Real World Disease Specific Programme is wholly owned by Adelphi Real World; ViiV healthcare is one subscriber and paid for the analysis Will Ambler, PhD, Adelphi Real World: Employee|ViiV Healthcare: The Adelphi Real World Disease Specific Programme is wholly owned by Adelphi Real World; ViiV healthcare is one subscriber and paid for the analysis Oliver-Thomas Carter, BSc, Adelphi Real World: Employee|ViiV Healthcare: The Adelphi Real World Disease Specific Programme is wholly owned by Adelphi Real World; ViiV healthcare is one subscriber and paid for the analysis Cindy Garris, MS, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee