P-2115. Clinical Presentation and Outcome of <i>Tuberculosis</i> in Chronic Kidney Disease Stage 4 and 5 from a high TB burden Country

Abstract Background Diagnosis and management of Tuberculosis (TB) in chronic kidney disease (CKD) is challenging. Our aim is to study clinical presentation and outcome in patients with stage 4 and 5 CKD from a high TB burden country. Methods All patients registered from May 2016 to June 2020 were included. Rifampicin resistance on GeneXpert test was excluded. Patients with CKD stage 4 and 5 were studied for demographics, TB history, clinical features, diagnoses, treatment success and mortality. CKD stage 4 and 5 were compared with other patients registered at the TB treatment center. Results Out of 828, 259 (31%) had CKD stage 4 and 5. Out of 259, 156 (60%) had extra-pulmonary TB (EPTB). Microbiological diagnosis done in 118 (45.51%), 25% in EPTB and 72.9% in pulmonary TB (PTB). TB culture was positive in 46 (17.8%), Isoniazid resistance [10] 21.7%. Treatment success was 80.7%. PTB was significantly associated with mortality (p=0.031). In CKD stage 4 and 5 treatment success was significantly lower with high mortality (p=0.033). Conclusion In CKD stage 4 and 5, EPTB is the most common presentation. Microbiological diagnosis could be achieved in one -fourth of EPTB. There is high INH resistance. The treatment success is low with high mortality and PTB is a significant risk factor for mortality. Disclosures All Authors: No reported disclosures