Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization
BMSC-EVs attenuate diabetes-exacerbated atherosclerosis by inhibiting vascular macrophage proliferation, migration, and foam cell formation via AMPK/mTOR signaling-regulated autophagy and macrophage polarization. BMSC-EVs thus hold promise as therapeutic agents for atherosclerosis.
Authors
- Xiantao Song
- Jinfan Tian (ORCID: https://orcid.org/0000-0002-3610-6814)
- Ziyu An
- Xueqi Wan (ORCID: https://orcid.org/0000-0003-4336-2549)
- Huan Zhang (ORCID: https://orcid.org/0009-0009-1420-0154)
- Xin Zhao (ORCID: https://orcid.org/0000-0003-3663-6097)
- Libo Liu (ORCID: https://orcid.org/0000-0003-0722-6398)
- Xueyao Yang (ORCID: https://orcid.org/0000-0003-1530-1802)
Institutions
- Capital Medical University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s12933-025-02603-0
- Citations
- 17
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 23.02
Funders
- National Natural Science Foundation of China
- Beijing Municipal Health Commission
- Shandong First Medical University