Rg3 inhibits hypoxia-induced tumor exosomes from boosting pancreatic cancer vasculogenic mimicry through the HIF-1α/LARS1/mTOR axis
Our findings revealed a novel mechanism through which Rg3 inhibits VM in PC by modulating hypoxia-induced tumor exosomes, offering novel experimental insights for PC treatment.
Authors
- Tingting Zhao (ORCID: https://orcid.org/0000-0001-6545-3842)
- Shengzhang Lin (ORCID: https://orcid.org/0000-0002-8815-3719)
- Zhaohong Wang (ORCID: https://orcid.org/0000-0002-9958-4944)
- Xufan Cai
- Hui Chen
- Heqi Bu
Institutions
- Wenzhou Medical University (CN)
- Ningbo No.6 Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.phymed.2025.156437
- Citations
- 6
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Natural Science Foundation of Zhejiang Province