Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways
This study is the first to propose linarin as a potential natural compound for alleviating HN by modulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways, providing a promising strategy for HN.
Authors
- Huifan Yu (ORCID: https://orcid.org/0000-0003-2936-5778)
- Zhengkun Wu (ORCID: https://orcid.org/0009-0009-5772-3895)
- Xuelai He
- Mao Xu
- Linsheng Huang
- Fei Li (ORCID: https://orcid.org/0009-0004-7499-7197)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0002-2922-9824)
- Tao Zhang (ORCID: https://orcid.org/0000-0001-6643-4686)
- Yue Chen (ORCID: https://orcid.org/0000-0003-4415-1380)
- Han Luo (ORCID: https://orcid.org/0000-0002-2808-0167)
- Ying Jiang (ORCID: https://orcid.org/0000-0002-1082-5052)
- Li Liu
- Lili Gui
- Yongshuai Qian
Institutions
- Hubei University of Medicine (CN)
- Hubei University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.phymed.2025.156440
- Citations
- 21
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 30.05
Funders
- Hubei Provincial Department of Education
- Hubei University of Medicine