Intradermal Advanced Glycation End-products Relate to Reduced Sciatic Nerve Structural Integrity in Type 2 Diabetes
This study is the first to show close correlations between reduced peripheral nerve integrity and both intradermal AGE deposition and arterial stiffness in individuals with T2D. These findings highlight a mechanistic link between glycation-related vascular injury and neuronal damage emphasizing the importance of cardiovascular risk management in preventing DSPN.
Authors
- Ζoltan Κender (ORCID: https://orcid.org/0000-0003-0745-1587)
- Lukas Schimpfle (ORCID: https://orcid.org/0000-0001-8917-7950)
- Felix Tobias Kurz (ORCID: https://orcid.org/0000-0001-7616-7147)
- Julia Szendroedi (ORCID: https://orcid.org/0000-0002-5185-8168)
- Martin Bendszus (ORCID: https://orcid.org/0000-0002-9094-6769)
- Christoph Matthias Mooshage (ORCID: https://orcid.org/0000-0003-3436-9298)
- Stefan Kopf (ORCID: https://orcid.org/0000-0002-6455-3769)
- Stephan Herzig (ORCID: https://orcid.org/0000-0003-3950-3652)
- Dimitrios Tsilingiris (ORCID: https://orcid.org/0000-0002-6864-4289)
- Sabine Heiland (ORCID: https://orcid.org/0000-0002-2796-3451)
- Johann M. E. Jende (ORCID: https://orcid.org/0000-0002-1387-9304)
- Thomas Fleming
Institutions
- Democritus University of Thrace (GR)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- University Hospital of Alexandroupolis (GR)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Clinical Neuroradiology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1007/s00062-024-01493-1
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Deutsche Diabetes Gesellschaft
- Universitätsklinikum Heidelberg