Effect of repurposed metabolic drugs on human macrophage polarization and antitumoral activity
This study reveals that targeting glutamine metabolism with CB839 effectively blocks the IL-4-induced anti-inflammatory phenotype in macrophages and enhances their tumor-killing capability. Our results provide a compelling rationale for repurposing metabolic drugs to create a pro-inflammatory tumor microenvironment, thereby potentially enhancing the efficacy of current immunotherapies.
Authors
- Annemarie Boerma (ORCID: https://orcid.org/0000-0001-5265-9593)
- Toos Daemen (ORCID: https://orcid.org/0000-0003-0166-512X)
- Ana Vizcaino-Castro (ORCID: https://orcid.org/0009-0000-5953-630X)
- César Oyarce (ORCID: https://orcid.org/0000-0002-0078-3282)
- Baukje Nynke Hoogeboom
- Shipeng Chen (ORCID: https://orcid.org/0000-0002-4659-6386)
Institutions
- University Medical Center Groningen (NL)
- Xiamen University (CN)
Publication Details
- Journal
- Clinical Immunology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.clim.2025.110440
- Citations
- 4
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Stichting De Cock-Hadders
- KWF Kankerbestrijding