Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

These results proposed that beneficial bacteria including the Lachnospiraceae family depletion cross-talk with acetoacetate and BHB accumulations followed by an increased abundance of driver bacteria including G. morbillorum, and M. morganii may reprogram polyp microenvironment leading to tumor initiation. Consequently, passenger bacteria accumulation like A. enteropelogenes, A.veronii, and F. nucleatum subsp. animalis cross-talking fumarate in the TME may aggravate cancer development. So, knowledge of TME bacteriome and metabolites might help in cancer prevention, early diagnosis, and a good prognosis.

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Publication Details

Journal
Annals of Clinical Microbiology and Antimicrobials
Published
2025-01-29
DOI
https://doi.org/10.1186/s12941-025-00777-9
Citations
3
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
2.42

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article

Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

Reza Ghotaslou, Fadhil S. Kamounah, Andrey O. Plotnikov, Hadi Feizi et al.
3 citations
Annals of Clinical Microbiology and Antimicrobials
Gut microbiota and health
2.42
article

Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

Reza Ghotaslou, Fadhil S. Kamounah, Andrey O. Plotnikov, Hadi Feizi, Hossein Samadi Kafil, Hiva Kadkhoda, Mohammad Sadrkabir, Alexander S. Balkin, Ekaterina S. Filonchikova, S YU Nikitin, Vladimir Kataev, Mohammad Ahangarzadeh Rezaee
article en
3 citations

Abstract

These results proposed that beneficial bacteria including the Lachnospiraceae family depletion cross-talk with acetoacetate and BHB accumulations followed by an increased abundance of driver bacteria including G. morbillorum, and M. morganii may reprogram polyp microenvironment leading to tumor initiation. Consequently, passenger bacteria accumulation like A. enteropelogenes, A.veronii, and F. nucleatum subsp. animalis cross-talking fumarate in the TME may aggravate cancer development. So, knowledge of TME bacteriome and metabolites might help in cancer prevention, early diagnosis, and a good prognosis.

Annals of Clinical Microbiology and AntimicrobialsVol. 24(1)
Roskilde University (DK), University of Copenhagen (DK), Islamic Azad University of Tabriz (IR), Tabriz University of Medical Sciences (IR), Urmia University (IR), Institute of Cellular and Intracellular Symbiosis (RU)
Tabriz University of Medical Sciences, University of Tabriz, Drug Applied Research Center, Tabriz University of Medical Sciences
Good health and well-being
Openalex Percentile: Top 13%
Gut microbiota and health
2.42
DOIOpen Access PDFOpenAlex
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Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk — Reza Ghotaslou, Fadhil S. Kamounah, et al. · Annals of Clinical Microbiology and Antimicrobials (2025) | TGRS Research Map | TGRS