Effect of FLASH proton therapy on primary bronchial epithelial cell organoids
No significant differences were found in DNA damage or gene expression profiles between CONV and FLASH. The organoid formation assay showed a prolonged detrimental effect in the FLASH-treated organoids, suggesting a more complex interaction of FLASH with lung epithelial cells. The results of this study contribute to the advancement of robust <i>in vitro</i> human lung models for investigating the mechanisms of action of FLASH, potentially facilitating the treatment of NSCLC patients with proton FLASH therapy.
Authors
- Pieter S. Hiemstra (ORCID: https://orcid.org/0000-0002-0238-5982)
- Annelies M. Slats (ORCID: https://orcid.org/0000-0001-8790-6793)
- Ernst van der Wal (ORCID: https://orcid.org/0000-0002-2362-8381)
- Marta Rovituso (ORCID: https://orcid.org/0009-0003-8269-1932)
- Merian E. Kuipers (ORCID: https://orcid.org/0000-0002-9771-9825)
- Krista C.J. van Doorn-Wink
- Floriane van Liefferinge
Institutions
- Leiden University Medical Center (NL)
- Proton Therapy Centre (CZ)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.ctro.2025.100927
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00