P-150. Antibiogram Creation at King Faisal Hospital in Kigali, Rwanda to Inform Antimicrobial Stewardship Priorities

Abstract Background Antimicrobial resistance (AMR) is a major global health challenge. King Faisal Hospital (KFH) in Kigali, Rwanda, is the country’s quaternary referral hospital. Creating antibiograms provides useful information for assessing the burden of resistance and for establishing pertinent antimicrobial use guidance.Figure 1:Susceptibility Patterns of Select Gram Negative Bacteria to Common Antibiotics Methods We analyzed all positive cultures at KFH from January 1, 2018 – December 3, 2023. An electronic laboratory system was used to extract data. Duplicate samples were excluded based on CLSI guidelines. Data were organized by organism and susceptibility to reported antibiotics was recorded. Using this raw data, we created yearly antibiograms that showcased susceptibility patterns over time. Results Susceptibilities of key Enterobacterales species were relatively low for ceftriaxone and cefepime but higher for piperacillin-tazobactam and meropenem; all were generally stable over time (Figure 1). Ciprofloxacin susceptibility for these organisms decreased over time. Methicillin (oxacillin) resistance in Staphylococcus aureus and vancomycin resistance in Enterococcus species were relatively rare and stable over time. Conclusion Antimicrobial resistance is increasing worldwide and determining local resistance patterns through antibiograms is one important step to impacting this global problem. Decreased susceptibility to some antibacterial drugs was noted at KFH which helps inform areas for future study and intervention. Challenges to data collection were variations in lab reporting, data, and storage collection systems in the past five years. These findings also provide a basis for the creation of an antimicrobial stewardship program at KFH. Disclosures All Authors: No reported disclosures