PD15, a steroidal saponin, induces apoptosis of HCT116 colorectal cancer cells via suppressing the Akt/GSK3β pathway
These findings indicate that PD15 could trigger apoptosis by suppressing the Akt/GSK3β signaling pathway in HCT116 cells.
Authors
- Ruili Li (ORCID: https://orcid.org/0000-0001-5112-3201)
- Yang Sun (ORCID: https://orcid.org/0000-0003-3271-1491)
- Yi Ding (ORCID: https://orcid.org/0000-0002-2158-3108)
- Haifeng Tang (ORCID: https://orcid.org/0000-0002-5073-0680)
- Kai Gao (ORCID: https://orcid.org/0000-0002-0771-7755)
- Yi Qiao (ORCID: https://orcid.org/0000-0002-1371-6775)
- Minna Yao
- Weiwei Li (ORCID: https://orcid.org/0000-0002-7328-0969)
- Yanhua Wang (ORCID: https://orcid.org/0000-0003-4678-0770)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-6911-0900)
- Jingwen Wang (ORCID: https://orcid.org/0000-0002-3450-9046)
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1093/jpp/rgae151
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shaanxi Administration of Traditional Chinese Medicine
- National Natural Science Foundation of China