Features of the neurological status of newborns from mothers with parvovirus B19 infection

To date, the issue of parvovirus B19 (B19V) infection in pregnant women and its impact on the fetus remains quite relevant. B19V is one of the causes of perinatal pathology, particularly non-immune fetal hydrops (NIFH), which can lead to intrauterine anemia, heart failure, and fetal death. Aim - to investigate the neurological status of newborns who underwent intrauterine treatment for NIFH caused by B19V infection. Materials and methods. A retrospective analysis of the medical histories of 32 pregnancies complicated by NIFH due to parvovirus B19 was conducted over the period 2022-2024 at the Perinatal Center in Kyiv. Intrauterine erythrocyte transfusions were performed on 11 fetuses with severe anemia. Neurological status was assessed using the HINE scale at 3 and 6 months of age. Results. Survival after treatment reached 72.7%, while mortality without treatment was 100%. A favorable prognosis for future neurological disorders was noted in 62.5% of the children, while 37.5% showed a risk of impairments. Conclusions. Intrauterine erythrocyte transfusions are effective in treating fetal anemia caused by B19V infection. However, neurological disorders remain possible, requiring continued follow-up of children after treatment. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. The authors declare no conflict of interest.