Xanthogranulomatous Cholecystitis in a 15-Year-Old Girl: A Case Report and Literature Review

Xanthogranulomatous cholecystitis (XGC) is a rare and severe variant of cholecystitis that poses significant diagnostic and surgical challenges. While predominantly seen in adults, its occurrence in pediatric patients is exceedingly rare, with very few cases documented in the literature. We present the case of a 15-year-old girl initially diagnosed with acute calculous cholecystitis who underwent a laparoscopic cholecystectomy. Intraoperatively, extensive pseudo-tumorous inflammation was identified, with fusion of the gallbladder into the omentum, duodenum, and colon, necessitating a subtotal cholecystectomy. Her postoperative recovery was complex, requiring endoscopic retrograde cholangiopancreatography (ERCP), and she was ultimately discharged after a prolonged hospital stay. Histopathological examination confirmed the diagnosis of XGC. This case highlights the complexities of managing this rare entity in pediatric patients.

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Journal
Cureus
Published
2025-01-29
DOI
https://doi.org/10.7759/cureus.78205
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
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article
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article

Xanthogranulomatous Cholecystitis in a 15-Year-Old Girl: A Case Report and Literature Review

Ishanth Devinda Jayewardene, Nestor Sabat, William Qian
Cureus
Cholangiocarcinoma and Gallbladder Cancer Studies
article

Xanthogranulomatous Cholecystitis in a 15-Year-Old Girl: A Case Report and Literature Review

Ishanth Devinda Jayewardene, Nestor Sabat, William Qian
article en

Abstract

Xanthogranulomatous cholecystitis (XGC) is a rare and severe variant of cholecystitis that poses significant diagnostic and surgical challenges. While predominantly seen in adults, its occurrence in pediatric patients is exceedingly rare, with very few cases documented in the literature. We present the case of a 15-year-old girl initially diagnosed with acute calculous cholecystitis who underwent a laparoscopic cholecystectomy. Intraoperatively, extensive pseudo-tumorous inflammation was identified, with fusion of the gallbladder into the omentum, duodenum, and colon, necessitating a subtotal cholecystectomy. Her postoperative recovery was complex, requiring endoscopic retrograde cholangiopancreatography (ERCP), and she was ultimately discharged after a prolonged hospital stay. Histopathological examination confirmed the diagnosis of XGC. This case highlights the complexities of managing this rare entity in pediatric patients.

CureusVol. 17(1)
The University of Sydney (AU), Charles Sturt University (AU), Royal North Shore Hospital (AU), UNSW Sydney (AU), Cooperative Trials Group for Neuro-Oncology (AU), Kensington Health (CA), Port Macquarie Base Hospital (AU)
Gender equality
Openalex Percentile: Top 97%
Cholangiocarcinoma and Gallbladder Cancer Studies
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Xanthogranulomatous Cholecystitis in a 15-Year-Old Girl: A Case Report and Literature Review — Ishanth Devinda Jayewardene, Nestor Sabat, et al. · Cureus (2025) | TGRS Research Map | TGRS