Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking

This study demonstrates that plasticizers may influence the pathogenesis of OP by targeting specific genes and pathways. And the molecular docking simulations indicate a distinct binding specificity between plasticizers and target proteins. These results provide a foundation for further investigation into the mechanisms by which plasticizers affect bone health. Future research should focus on the dose-response relationship between plasticizer exposure and the risk of OP, and explore potential intervention measures to mitigate the adverse effects of plasticizers on bone health.