An Efficient Catalyst‐Free Protocol for the Synthesis of Various CNContaining Heterocycles at Ambient Temperature
ABSTRACT Herein, we reported an efficient synthetic protocol to access various N‐containing heterocycles at ambient temperature without using any catalysts and additives. The protocol showed good tolerance to dozens of substrates affording quinoxalines, thiazoles, and imidazoles with isolated yields of up to 94%, wherein 26 examples were synthesized in total. Moreover, this method was also readily applicable to gram‐scale synthesis. Finally, a plausible reaction mechanism was proposed according to the experimental results.
Authors
- Haibo Zhu (ORCID: https://orcid.org/0000-0002-9141-8204)
- Qiangwen Fan (ORCID: https://orcid.org/0000-0001-5593-6904)
- Zongbo Xie (ORCID: https://orcid.org/0000-0002-6957-6433)
- Xinmei Xie
- Huijun Ren (ORCID: https://orcid.org/0000-0003-2869-6188)
- Qiuyun Huang (ORCID: https://orcid.org/0009-0004-0733-174X)
- Liu Yang
- Zhang-Gao Le
Institutions
- East China University of Technology (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1002/jhet.4948
- Citations
- 1
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province