Comparison of plasma concentration and sedative effect of sublingual and intranasal dexmedetomidine in children: A double‐blind randomised controlled study
This study compared the pharmacokinetics and sedative effects of sublingual versus intranasal dexmedetomidine in children, finding that intranasal administration resulted in significantly higher peak plasma concentration and faster time to peak concentration. Both routes achieved comparable sedation, parental separation anxiety scores and mask acceptance, with no significant adverse effects observed.
Authors
- A. R. Khan (ORCID: https://orcid.org/0009-0001-1891-1473)
- Souvik Maitra (ORCID: https://orcid.org/0000-0002-2328-9201)
- Thirumurthy Velpandian (ORCID: https://orcid.org/0000-0003-0334-5197)
- Kanil Ranjith Kumar (ORCID: https://orcid.org/0000-0001-6490-5667)
- Bikash Ranjan Ray (ORCID: https://orcid.org/0000-0003-1461-1518)
- Renu Sinha (ORCID: https://orcid.org/0000-0002-4786-6413)
Institutions
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Acta Anaesthesiologica Scandinavica
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1111/aas.14583
- Citations
- 5
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 10.95