Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study
There is no causal relationship between female sex hormones and IBD, but male SHBG and testosterone are positively correlated with the risk of IBD and IBD promotes elevated levels of SHBG and testosterone in males, suggesting that sex hormones play different roles in IBD patients of different sexes.
Authors
- Shuangying Tian
- Zhihui Tao (ORCID: https://orcid.org/0009-0008-1882-7950)
- Kaiwen Wang (ORCID: https://orcid.org/0000-0003-2881-8181)
- Yu Lou (ORCID: https://orcid.org/0000-0002-2015-3501)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fendo.2025.1338701
- Citations
- 1
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.67