Crowned Dens Syndrome Presenting as Failure to Thrive in a Patient With Moderate Cognitive Impairment

Crowned dens syndrome (CDS) is a rare condition characterized by the deposition of calcium pyrophosphate (CPP) or hydroxyapatite crystals around the odontoid process of the C2 vertebra, often presenting with acute neck pain, reduced cervical mobility, and systemic inflammatory response. This case describes a 68-year-old male patient with a history of type 2 diabetes, hypertension, and benign prostatic hyperplasia who presented with generalized weakness and failure to thrive. This atypical presentation initially masked symptoms of CDS, delaying the diagnosis until the patient developed acute neck pain and stiffness, prompting further imaging. CT imaging revealed calcifications around the odontoid process, confirming the diagnosis of CDS. Given the severity of the symptoms, corticosteroids were administered, resulting in significant clinical improvement. This case highlights the importance of considering CDS in the differential diagnosis of older patients presenting with systemic inflammatory symptoms and unexplained neck pain, particularly when initial workups are inconclusive.

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Publication Details

Journal
Cureus
Published
2025-01-28
DOI
https://doi.org/10.7759/cureus.78158
Citations
2
Primary Topic
Skin and Cellular Biology Research
Type
article
Field-Weighted Citation Impact
2.30
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article

Crowned Dens Syndrome Presenting as Failure to Thrive in a Patient With Moderate Cognitive Impairment

Gregory L Stone, Gerardo Rogelio Robaina Castellanos, Amir A Razmjou
2 citations
Cureus
Skin and Cellular Biology Research
2.30
article

Crowned Dens Syndrome Presenting as Failure to Thrive in a Patient With Moderate Cognitive Impairment

Gregory L Stone, Gerardo Rogelio Robaina Castellanos, Amir A Razmjou
article en
2 citations

Abstract

Crowned dens syndrome (CDS) is a rare condition characterized by the deposition of calcium pyrophosphate (CPP) or hydroxyapatite crystals around the odontoid process of the C2 vertebra, often presenting with acute neck pain, reduced cervical mobility, and systemic inflammatory response. This case describes a 68-year-old male patient with a history of type 2 diabetes, hypertension, and benign prostatic hyperplasia who presented with generalized weakness and failure to thrive. This atypical presentation initially masked symptoms of CDS, delaying the diagnosis until the patient developed acute neck pain and stiffness, prompting further imaging. CT imaging revealed calcifications around the odontoid process, confirming the diagnosis of CDS. Given the severity of the symptoms, corticosteroids were administered, resulting in significant clinical improvement. This case highlights the importance of considering CDS in the differential diagnosis of older patients presenting with systemic inflammatory symptoms and unexplained neck pain, particularly when initial workups are inconclusive.

CureusVol. 17(1)
University of California, Los Angeles (US), Olive View-UCLA Medical Center (US), VA Greater Los Angeles Healthcare System (US)
Openalex Percentile: Top 16%
Skin and Cellular Biology Research
2.30
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