Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice
Our findings highlight a novel mechanism by which zinc ions regulate inflammation in SCI by upregulating IKBα and inhibiting NF-κB activation. This suggests potential therapeutic applications of zinc ions in SCI and other inflammatory conditions, warranting further investigation into their clinical benefits.
Authors
- Daoyong Li (ORCID: https://orcid.org/0000-0002-1501-4240)
- Mingyu Bai
- Xifan Mei (ORCID: https://orcid.org/0000-0003-3698-0525)
- Zhaoliang Shen
- He Tian (ORCID: https://orcid.org/0000-0001-8105-9773)
- Yang Cui (ORCID: https://orcid.org/0009-0001-9776-7341)
- Zhanpeng Guo
Institutions
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fphar.2025.1510372
- Citations
- 7
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Natural Science Foundation of China