Formulation development and evaluation of bilayered tablets of amlodipine as immediate release layer and metaclopromide as sustained release layer

In the present study an attempt was made to prepare bilayer tablets of Amlodipine Besylate and Metoclopromide Succinate sustained release layer, which remains in stomach for prolonged period of time in a view to maximize bioavailability of drug, by using various concentrations of polymers, fifteen formulations of Metoclopromide having polymers at different concentration levels were prepared of which three formulations F8, F10, F13 showed excellent drug release profiles so these formulations were selected for the preparation of bilayer floating tablets. Amlodipine Besylate layer (immediate release) A1 was prepared by using sodium starch glycolate as super disintegrant, which showed excellent drug release so the composition of immediate release layer is kept constant in all formulations. Best formulations from both the layers were selected and formulated as bilayer tablets i.e (A1+F8), (A1+F10), (A1+F13) and these formulationsshowed excellent post compression C invitro drug release, hence all the three formulations were selected asoptimized formulations.