SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin
Our study demonstrates that SHP2 is involved in migration, invasion, and EMT in TNBC cells by modulating β-catenin. Manipulating SHP2 expression or its target protein β-catenin may offer a novel approach to TNBC therapy.
Authors
- Qing Han (ORCID: https://orcid.org/0000-0003-1272-9651)
- Jingjing Zhu (ORCID: https://orcid.org/0000-0003-2172-6137)
- Huang Cheng
- Huaibin Zhou (ORCID: https://orcid.org/0000-0002-7897-1937)
- Shihan Qian
Institutions
- Wenzhou Medical University (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Shandong Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1007/s00432-025-06097-x
- Citations
- 1
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province