PMAIP1 regulates the progression of follicular thyroid carcinoma through the Wnt3/FOSL1 pathway
In conclusion, our research demonstrated that PMAIP1 emerges as a novel pro-cancer factor in FTC, and its knockdown significantly inhibited the proliferation and metastasis of FTC both <i>in vivo</i> and <i>in vitro</i>. Mechanistically, PMAIP1 regulated FOSL1 by modulating the Wnt signaling pathway, thereby promoting FTC progression. Targeting PMAIP1 may present a promising therapeutic strategy for FTC.
Authors
- Xia Jiang (ORCID: https://orcid.org/0000-0003-4572-0039)
- Dongyun Li (ORCID: https://orcid.org/0000-0003-2735-1639)
- Zengren Zhao (ORCID: https://orcid.org/0000-0002-4802-3581)
- Chuan‐Min Zhou (ORCID: https://orcid.org/0000-0002-5975-4603)
- Longfei Kang (ORCID: https://orcid.org/0000-0002-1374-6384)
- Fangjian Shang (ORCID: https://orcid.org/0000-0001-9480-3223)
- Bo Liu (ORCID: https://orcid.org/0000-0002-2825-1587)
- Yifang Wang (ORCID: https://orcid.org/0000-0003-1980-1126)
- Haobo Wang (ORCID: https://orcid.org/0000-0002-3606-5282)
- Zhongxin Li (ORCID: https://orcid.org/0000-0002-6375-1667)
- Bo Pang (ORCID: https://orcid.org/0000-0002-0323-5484)
Institutions
- Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fonc.2025.1502391
- Citations
- 3
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.88