Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model
We show that the BALB/c mice are a mouse strain of choice for model of adjuvant-free epicutaneous sensitization through the disrupted skin barrier and following food allergy development. Our results highlight the significant influence of genetic background and microbiota on food allergy susceptibility, emphasizing the complex interplay between these factors in the allergic response.
Authors
- Dagmar Šrůtková (ORCID: https://orcid.org/0000-0003-0054-5396)
- Anna Šedivá (ORCID: https://orcid.org/0000-0001-7730-2304)
- Anna Jelinkova (ORCID: https://orcid.org/0009-0005-4880-8126)
- Andrea Poloučková
- Tomas Thon
- Zuzana Jirásková Zákostelská (ORCID: https://orcid.org/0000-0002-6695-8188)
- Peter J. Makovicky (ORCID: https://orcid.org/0000-0002-9351-7396)
- Štěpán Coufal (ORCID: https://orcid.org/0000-0001-6950-1813)
- Helena Tlaskalová‐Hogenová (ORCID: https://orcid.org/0000-0003-0360-3563)
- Miloslav Kverka (ORCID: https://orcid.org/0000-0002-1335-5252)
- Eliška Kopelentová
- Martin Schwarzer
- Tereza Hornikova
Institutions
- University of Ostrava (CZ)
- Charles University (CZ)
- University Hospital in Motol (CZ)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1509691
- Citations
- 5
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Agentura Pro Zdravotnický Výzkum České Republiky