Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway
These results suggest that SESN2 is a negative regulator of ferroptosis. Enhancing the expression of SESN2 can alleviate ferroptosis through the activation of the System Xc-/GPX4 pathway. By integrating bioinformatics analysis with mechanistic exploration, this study revealed that ferroptosis plays a crucial role in IR-induced BMVECs injury, with SESN2 acting as a negative regulator via the System Xc-/GPX4 pathway.
Authors
- Guoqiang Zhu (ORCID: https://orcid.org/0000-0002-5039-6213)
- Lijun Qin (ORCID: https://orcid.org/0009-0001-9727-159X)
- Jingling Jin (ORCID: https://orcid.org/0000-0002-4365-1837)
- Jingjing Ren (ORCID: https://orcid.org/0000-0002-6774-9791)
- Hongxia Wang (ORCID: https://orcid.org/0000-0003-1433-3693)
- Dan Li (ORCID: https://orcid.org/0000-0002-4831-5103)
- Haixue Zheng (ORCID: https://orcid.org/0000-0001-6850-1379)
- Zhao‐Ming Ge (ORCID: https://orcid.org/0000-0002-8006-1000)
- Jiejie Hu (ORCID: https://orcid.org/0000-0003-2110-9665)
Institutions
- Lanzhou Jiaotong University (CN)
- Lanzhou Veterinary Research Institute (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Lanzhou University Second Hospital (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fgene.2024.1504114
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Natural Science Foundation of Gansu Province
- Lanzhou Science and Technology Bureau