Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity
Our findings demonstrate that β-cell autophagy is critical to cell survival/function. Defective β-cell autophagy induces ER stress, alters pathways of antigen production, and enhances MHC-I/HLA-I presentation to surveilling immune cells. Overall, our results suggest that defects in autophagy make β-cells more susceptible to immune attack and destruction.
Authors
- Saptarshi Roy (ORCID: https://orcid.org/0000-0002-4649-0741)
- Justin J. Crowder
- Amelia K. Linnemann (ORCID: https://orcid.org/0000-0001-7356-4876)
- Charanya Muralidharan
- Jon D. Piganelli (ORCID: https://orcid.org/0000-0003-2699-9011)
- Matthew C. Austin (ORCID: https://orcid.org/0000-0002-8920-4311)
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1504583
- Citations
- 10
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 20.06
Funders
- International Development Research Centre
- National Institutes of Health
- School of Medicine, Indiana University
- National Center for Advancing Translational Sciences