Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects
Taken together, our findings suggest that male rats may be more susceptible to short-and long-term consequences of rmTBI in the applied model. These sex differences should be considered when translating preclinical biomarker candidates to the clinic. Understanding these differences could guide the diagnosis and treatment of CTE in a personalized manner, offering hope for more effective treatments in the future.
Authors
- Rodrigo Moraga‐Amaro (ORCID: https://orcid.org/0000-0002-0359-3142)
- Óscar Moreno (ORCID: https://orcid.org/0000-0002-8975-1411)
- Jordi Llop (ORCID: https://orcid.org/0000-0002-0821-9838)
- Marion Bankstahl (ORCID: https://orcid.org/0000-0002-5775-188X)
- Jens P. Bankstahl (ORCID: https://orcid.org/0000-0003-4735-4490)
Institutions
- University of Veterinary Medicine Vienna (AT)
- Medizinische Hochschule Hannover (DE)
- CIC biomaGUNE (ES)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fnmol.2025.1488261
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Deutsche Forschungsgemeinschaft
- Agencia Estatal de Investigación