Transcriptomic signatures of severe acute mountain sickness during rapid ascent to 4,300 m
The findings highlight the importance of hemoglobin-related genes and the CREB pathway in AMS susceptibility and adaptation to hypoxia. The differential regulation of these pathways provides novel insights into the biological mechanisms underlying AMS. The proposed biomarker panels offer promising avenues for the early diagnosis and prediction of AMS risk, which could enhance preventive and therapeutic strategies.
Authors
- Aarti Gautam (ORCID: https://orcid.org/0000-0003-3132-5599)
- Ruoting Yang (ORCID: https://orcid.org/0000-0002-8289-1999)
- Beth A. Beidleman (ORCID: https://orcid.org/0000-0001-8854-4210)
- Robert C. Roach (ORCID: https://orcid.org/0000-0002-7998-8976)
- Rasha Hammamieh (ORCID: https://orcid.org/0000-0001-8643-6232)
Institutions
- U.S. Army Research Institute of Environmental Medicine (US)
- United States Army (US)
- University of Colorado Anschutz Medical Campus (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fphys.2024.1477070
- Citations
- 4
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- U.S. Army Medical Research and Development Command