Chemotaxonomy and Bioactive Potential of High‐Mountain <i>Plantago atrata</i>
Plantago atrata Hoppe is a high-altitude mountain plant exposed to harsh environmental factors. This study aims to elucidate the ecological, phytochemical and pharmacological characteristics of this lesser-known plantain. Despite nutrient-poor peat soil, the leaves of P. atrata contained increased levels of phosphorus, potassium and calcium, and the anatomy revealed an isobilateral mesophyll. Molecular taxonomic identification and phylogenetic analyses confirmed the classification of the studied plant as P. atrata and its clustering with narrow-leaved plantains growing in extreme conditions. Detailed phytochemical profiles revealed primary and secondary metabolites that can be used as taxonomic identifiers and for bioactivity studies. The methanol fraction enriched in phenolic compounds appeared biologically active-by displaying limited antimicrobial activity, however, it possessed significant radical-scavenging and anti-inflammatory capacity. The data demonstrate that P. atrata's leaf parameters and phytochemical arsenal assure plant survival and reveal the plantain's pharmaceutical potential in inhibiting inflammation via the classical pathway of Complement activation.
Authors
- Mariya Rogova
- Georgi Bonchev (ORCID: https://orcid.org/0000-0002-6059-8003)
- Boris V. Tsenov
- Danijela Mišić (ORCID: https://orcid.org/0000-0002-5419-0773)
- Georgi Ivanov
- Uroš Gašić (ORCID: https://orcid.org/0000-0001-5384-8396)
- Krasimir Rusanov (ORCID: https://orcid.org/0000-0001-8131-3364)
- Ginka Cholakova (ORCID: https://orcid.org/0000-0003-4375-5115)
- Kalina Alipieva (ORCID: https://orcid.org/0000-0003-2395-5339)
- Zhenya Yordanova (ORCID: https://orcid.org/0000-0002-6007-6491)
- Ivanka Tsacheva (ORCID: https://orcid.org/0000-0002-3308-4154)
- Anita Tosheva (ORCID: https://orcid.org/0000-0002-4606-1672)
- Vanya Bogoeva (ORCID: https://orcid.org/0000-0001-7951-1089)
- Nikolina Mihaylova (ORCID: https://orcid.org/0000-0001-8582-9296)
- Viktoria Hristova (ORCID: https://orcid.org/0000-0001-5482-7001)
- Ganka Chaneva (ORCID: https://orcid.org/0000-0002-5650-5476)
- Svetoslav Anev (ORCID: https://orcid.org/0000-0002-8802-2751)
- Miroslava Zhiponova (ORCID: https://orcid.org/0000-0001-7333-6558)
- Alexandra Kapogianni (ORCID: https://orcid.org/0009-0003-4419-1603)
- Milena Nikolova Petrova
- Мila Rusanova (ORCID: https://orcid.org/0000-0001-8964-6411)
- Aneliya Raycheva
- Desislava Mantovska (ORCID: https://orcid.org/0000-0002-7872-3415)
- Valya Vassileva (ORCID: https://orcid.org/0000-0002-9055-8002)
- Petya Hristova
- Detelina Petrova
- Dimitrina Koleva
- Dimitar Danchev
Institutions
- University of Forestry (BG)
- Bulgarian Academy of Sciences (BG)
- University of Belgrade (RS)
- Institute of Organic Chemistry with Centre of Phytochemistry (BG)
- Institute of Molecular Biology (BG)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- AgroBio (BR)
- Institute of Plant Physiology and Genetics (BG)
- Agrobioinstitute (BG)
- Institute of Physics Belgrade (RS)
- Sofia University "St. Kliment Ohridski" (BG)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1002/cbdv.202402433
- Citations
- 1
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.75