Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders
There was no effect of high-dose ondansetron on SP. However, when used as an augmentation to SRIs, ondansetron reduced overall OCD severity, which may be related to changes in the "hubness" of the sensorimotor cortex. Ondansetron's ability to modulate brainstem connectivity may underlie its variable effectiveness in reducing SP.
Authors
- Wayne K. Goodman (ORCID: https://orcid.org/0000-0001-6717-082X)
- James W. Murrough (ORCID: https://orcid.org/0000-0001-6286-1242)
- Katherine E. Burdick (ORCID: https://orcid.org/0000-0003-4417-4988)
- Russell H. Tobe (ORCID: https://orcid.org/0000-0002-7738-8344)
- Nicolette Recchia
- Katherine Collins (ORCID: https://orcid.org/0000-0002-4351-3135)
- Emily Stern (ORCID: https://orcid.org/0000-0001-7805-594X)
- Dan V. Iosifescu (ORCID: https://orcid.org/0000-0002-2512-2835)
- Evan Leibu
- Goi Khia Eng (ORCID: https://orcid.org/0000-0001-7189-2868)
- Laura B. Bragdon (ORCID: https://orcid.org/0000-0001-6768-4986)
- Barbara Coffey
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1176/appi.ajp.20240294
- Citations
- 9
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 20.76