Analysis of trial confirms efficacy of esketamine nasal spray in TRD

Several sensitivity analyses of a Phase 3b trial have demonstrated that esketamine nasal spray was consistently more efficacious than extended‐release quetiapine in patients with treatment‐resistant depression (TRD). The additional analyses of the ESCAPE‐TRD trial used multiple thresholds for remission and relapse. Study results were published online Dec. 2, 2024, in The British Journal of Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-01-29
DOI
https://doi.org/10.1002/pu.31276
Primary Topic
Mast cells and histamine
Type
article
Field-Weighted Citation Impact
0.00
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article

Analysis of trial confirms efficacy of esketamine nasal spray in TRD

The Brown University Psychopharmacology Update
Mast cells and histamine
article

Analysis of trial confirms efficacy of esketamine nasal spray in TRD

article en

Abstract

Several sensitivity analyses of a Phase 3b trial have demonstrated that esketamine nasal spray was consistently more efficacious than extended‐release quetiapine in patients with treatment‐resistant depression (TRD). The additional analyses of the ESCAPE‐TRD trial used multiple thresholds for remission and relapse. Study results were published online Dec. 2, 2024, in The British Journal of Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(3)
Openalex Percentile: Top 98%
Mast cells and histamine
DOISourceOpenAlex
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Analysis of trial confirms efficacy of esketamine nasal spray in TRD · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS