Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs
Ethambutol (EMB) is a first-line anti-tuberculosis drug that is also considered in treatment regimens for infections caused by non-tuberculous mycobacteria (NTM). EMB targets the arabinosyl transferases EmbCAB, which are important for the synthesis of cell wall constituents. To further explore and narrow down the structural variability of EMB, we synthesized three series of new EMB analogs. We tested their activity against <i>Mycobacterium tuberculosis</i>, <i>Mycobacterium smegmatis</i>, <i>Mycobacterium abscessus</i> and <i>Mycobacterium intracellulare</i>. Only analogs that very closely resembled EMB showed comparable antimycobacterial activity.
Authors
- Rana Abdelaziz (ORCID: https://orcid.org/0000-0002-9581-604X)
- Lea Mann
- Mohammad Abdel‐Halim (ORCID: https://orcid.org/0000-0003-1326-4219)
- Norbert Reiling (ORCID: https://orcid.org/0000-0001-6673-4291)
- Peter Imming (ORCID: https://orcid.org/0000-0003-2178-3887)
- Mthandazo Dube (ORCID: https://orcid.org/0000-0002-1043-0480)
- Adrian Richter (ORCID: https://orcid.org/0000-0002-0062-7896)
- Dina Robaa (ORCID: https://orcid.org/0000-0003-4297-8130)
Institutions
- German Center for Infection Research (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- Martin Luther University Halle-Wittenberg (DE)
- German University in Cairo (EG)
Publication Details
- Journal
- Molecules
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3390/molecules30030600
- Citations
- 2
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Deutscher Akademischer Austauschdienst
- Bundesministerium für Bildung und Forschung