Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens
The vaccine developed in this study provides complete protection against divergent H5N1 AIV strains in chickens, offering a promising approach for the future development of mRNA vaccines against multivalent avian influenza subtypes.
Authors
- Huiying Fan
- Yong-Fei Zhou
- Ming Liao (ORCID: https://orcid.org/0000-0001-8731-4528)
- Junyu Zhu (ORCID: https://orcid.org/0000-0002-7826-2516)
- Chongyu Tian (ORCID: https://orcid.org/0000-0003-3398-5208)
- Wanbo Tai (ORCID: https://orcid.org/0000-0002-9864-8993)
- Xiang Ao (ORCID: https://orcid.org/0000-0001-8851-7706)
- Huixin Chen (ORCID: https://orcid.org/0000-0003-3843-4405)
- Yanjuan He (ORCID: https://orcid.org/0000-0001-9905-0160)
- Shiqian Wang (ORCID: https://orcid.org/0009-0007-0007-5650)
- De‐Ming Kong (ORCID: https://orcid.org/0000-0002-9216-8040)
- Zhaoyang Wang (ORCID: https://orcid.org/0000-0003-0678-0346)
- X. Liao
Institutions
- South China Agricultural University (CN)
- Key Laboratory of Guangdong Province (CN)
- Shenzhen Bay Laboratory (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s12951-025-03156-w
- Citations
- 10
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.54
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China