6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy
6-TG exerted a significant inhibitory effect on EV71 infection in vitro and prevented EV71-induced the complete autophagy by decreasing BIRC3 expression. Our work provided a basis for the further development of 6-TG as a therapy for EV71-associated HFMD.
Authors
- Ruining Lyu (ORCID: https://orcid.org/0000-0001-7473-2181)
- Yating He (ORCID: https://orcid.org/0009-0007-2337-0580)
- Qiao You (ORCID: https://orcid.org/0009-0008-6306-717X)
- Zhiwei Wu (ORCID: https://orcid.org/0000-0002-0672-948X)
- Yurong Cai (ORCID: https://orcid.org/0000-0003-1942-8931)
- Fang Zhang (ORCID: https://orcid.org/0000-0002-3506-8924)
- Na Jiang (ORCID: https://orcid.org/0000-0003-4156-4737)
- Deyan Chen (ORCID: https://orcid.org/0000-0001-7351-4617)
- Jing Wu (ORCID: https://orcid.org/0009-0001-4400-0577)
- Ye Liu (ORCID: https://orcid.org/0009-0002-6601-4141)
Institutions
- Fujian Medical University (CN)
- Bengbu Medical College (CN)
- Zunyi Medical University (CN)
- Anhui University of Finance and Economics (CN)
- Tianjin First Center Hospital (CN)
- Ningxia Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
- Tianjin Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s12866-025-03752-8
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Ningxia University
- National Natural Science Foundation of China
- Jinan University
- Nanjing University