Breaking Barriers: A Triumph over Infertility in Swyer’s Syndrome

This case study examines the comprehensive fertility treatment and eventual successful conception of a patient with Swyer’s syndrome. It emphasizes the impact of suitable luteal support on reproductive outcomes. The patient underwent a thorough evaluation including karyotyping, laparoscopy, and gonadectomy. She then pursued donor oocytes in vitro fertilization (IVF) cycles, which were preceded by an estradiol challenge to evaluate endometrial receptivity. Human chorionic gonadotropin (hCG) was used for luteal phase support in the third IVF attempt after two previous unsuccessful cycles. The third IVF cycle, which included injection hCG for luteal support, led to successful implantation and conception. The pregnancy was uneventful, and the patient delivered a healthy baby via caesarean section at 37 weeks gestation. This case underscores the intricate management required for infertility in patients with gonadal dysgenesis. The positive outcome with hCG luteal support suggests its potential role in enhancing endometrial receptivity and implantation success in IVF treatments.