Study Protocol for ‘PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity’
This study's results are expected to offer critical insights into the neural mechanisms underlying the effects of psilocybin-assisted therapy in treating OCD, and whether these correlate with changes in the cognitive features of the condition. As a secondary aim, it will ascertain whether a low, tolerable dose is a feasible and efficacious clinical treatment, and will provide crucial data to guide the design of a potential follow-up randomised control trial (RCT).
Authors
- Pedro Castro-Rodrigues (ORCID: https://orcid.org/0000-0002-3911-7164)
- Martina Chiera
- Ana Frota Lisboa Pereira de Souza (ORCID: https://orcid.org/0009-0002-1304-1613)
- Dea Siggaard Stenbæk (ORCID: https://orcid.org/0000-0002-5439-4637)
- Mairead Healy
- Jonny Martell (ORCID: https://orcid.org/0000-0002-4194-7669)
- Robin Lester Carhart-Harris (ORCID: https://orcid.org/0000-0002-6062-7150)
- David Erritzøe (ORCID: https://orcid.org/0000-0002-7022-6211)
- Naomi Fineberg (ORCID: https://orcid.org/0000-0003-1158-6900)
- Kate Godfrey (ORCID: https://orcid.org/0000-0002-2578-2382)
- Luca Pellegrini (ORCID: https://orcid.org/0000-0002-2855-2865)
- Sean O’Connor (ORCID: https://orcid.org/0000-0001-5427-243X)
- Trevor William Robbins (ORCID: https://orcid.org/0000-0003-0642-5977)
- Joseph Peill (ORCID: https://orcid.org/0000-0003-0281-4617)
- David Nutt (ORCID: https://orcid.org/0000-0002-6423-9411)
- Hakjun Lee (ORCID: https://orcid.org/0000-0002-5777-4256)
- Cyrus Rohani-Shukla
- Robin J. Tyacke
- Sara Reed
- Maria Papasyrou
Institutions
- Champalimaud Foundation (PT)
- University of Copenhagen (DK)
- University of Hertfordshire (GB)
- University of Trieste (IT)
- University of California, San Francisco (US)
- University of Cambridge (GB)
- Hertfordshire Partnership University NHS Foundation Trust (GB)
- Cambridge School (PT)
- Bridge University (SS)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- Imperial College London (GB)
- IT University of Copenhagen (DK)
- University of Bologna (IT)
Publication Details
- Journal
- Cureus
- Published
- 2025-01-29
- DOI
- https://doi.org/10.7759/cureus.78171
- Citations
- 2
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.61