Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer
In conclusion, DAAM1 functions as an oncogene and is immunologically implicated in pancreatic cancer, these findings suggest that DAAM1 may serve as a promising therapeutic target for the clinical management of pancreatic cancer.
Authors
- Jie Mei (ORCID: https://orcid.org/0000-0001-7799-8129)
- Yichao Zhu (ORCID: https://orcid.org/0000-0003-3499-8510)
- Jing Sun (ORCID: https://orcid.org/0000-0001-9517-9872)
- Jiadong Pan (ORCID: https://orcid.org/0000-0002-5651-9122)
- Jiayue Yang (ORCID: https://orcid.org/0000-0001-8463-0883)
- Zhou Ji
- Rui Xu (ORCID: https://orcid.org/0000-0001-5116-4193)
- Yan Shen (ORCID: https://orcid.org/0000-0002-7895-2963)
- Mengyun Wan
Institutions
- Jiangsu University (CN)
- Nantong University (CN)
- First People's Hospital of Kunshan (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Jiangsu Province Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s12935-024-03631-8
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing Medical University