PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome
These studies demonstrate a pathological role of PP2A activity loss in the cause of MFS and implicate that activation of PP2A may serve as a novel therapeutic strategy to limit MFS progression, including aortic aneurysm formation.
Authors
- Zhiyong Lin (ORCID: https://orcid.org/0000-0002-9663-3886)
- Goutham Narla (ORCID: https://orcid.org/0000-0003-4098-4203)
- Nianguo Dong (ORCID: https://orcid.org/0000-0001-5437-599X)
- Alejandra Valdivia (ORCID: https://orcid.org/0000-0003-1492-5066)
- Bradley G. Leshnower (ORCID: https://orcid.org/0000-0002-2290-1729)
- Philip A. Klenotic (ORCID: https://orcid.org/0000-0001-8429-0145)
- Xianming Zhou (ORCID: https://orcid.org/0009-0007-3712-4743)
- Qian Xu (ORCID: https://orcid.org/0000-0001-7061-7282)
- Xingjian Hu (ORCID: https://orcid.org/0000-0002-8554-6138)
Institutions
- Central South University (CN)
- Emory University (US)
- University of Michigan (US)
- Wuhan Union Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Case Western Reserve University (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23494
- Citations
- 1
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 1.82