Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), <i>HBA1</i> :c.84G > T] in a Large Thai cohort
Hb Hekinan is a prevalent α-globin variant that is often undetected by HPLC but reliably identified using IEF. These findings highlight the importance of incorporating IEF for accurate diagnosis of Hb Hekinan. Most cases are clinically benign, even when interacting with other thalassemia syndromes or Hb variants.
Authors
- Jidapa Jaitheang
- Amornchai Suksusut
- Noppacharn Uaprasert (ORCID: https://orcid.org/0000-0003-4562-9139)
- Pranee Sutcharitchan
- Ponlapat Rojnuckarin (ORCID: https://orcid.org/0000-0001-7912-1996)
- Manussavee Prapphal
Institutions
- Chulalongkorn University (TH)
- King Chulalongkorn Memorial Hospital (TH)
Publication Details
- Journal
- Hematology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1080/16078454.2025.2456679
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63